The Ivanov Lab is interested in developing separation- and mass spectrometry-based technologies to answer challenging biomedical questions. The current research of the Ivanov Lab focuses mainly on the following areas: 1. deep proteomic and multi-omic profiling of limited cell populations (down to single cells) for basic biology and personalized medicine applications; 2. characterization of proteoforms, protein complexes and protein interactions; and 3. exploration of extracellular microvesicles as new tools for diagnostics and therapy development.
Numerous fields of biomedical research could benefit from the availability of highly sensitive methods to define specific phenotypic, physiological or activation states in microscopic amounts of various biological or clinical specimens by measuring enormously complex and highly dynamic molecular interplays in the proteome.
The analysis of intact proteins, their proteoforms and protein complexes is a growing area of interest in the biotech industry and fundamental biology as mass spectrometers become ever higher resolving and sensitive.
Extracellular vesicles (EVs) are phospholipid bilayer membrane-enclosed structures containing RNAs, proteins, lipids, metabolites, and other molecules, secreted by various cells into physiological fluids. EV-mediated transfer of biomolecules is a critical component of a variety of physiological and pathological processes. Potential applications of EVs in novel diagnostic and therapeutic strategies have brought increasing attention. Learning the biology of EVs could help researchers better understand pathological conditions like cancer and cardiovascular diseases.
140 The Fenway, Room 416TF (Mailstop 412TF)
Barnett Institute of Chemical and Biological Analysis,
360 Huntington Avenue, 412TF
Boston, MA, 02115, USA